abstract：:Telocytes (TCs) represent a new distinct type of interstitial cells found in many organs, including lungs. TCs are mainly defined by a small cellular body from which arise very long (hundreds of micrometers) extensions named telopodes. During the last years, TCs were characterized in respect with their microRNA profil...

journal_title：Histology and histopathology

authors： Song D,Cretoiu D,Cretoiu SM,Wang X

更新日期：2016-12-01 00:00:00

abstract：:This study was conducted to determine the effects of extracts obtained from both normal and denervated muscles on different muscle types. Wistar rats were used and were divided into a control group and four experimental groups. Each experimental group was treated intraperitoneally during 10 consecutive days with a dif...

journal_title：Histology and histopathology

authors： Agüera E,Castilla S,Luque E,Jimena I,Leiva-Cepas F,Ruz-Caracuel I,Peña J

更新日期：2016-12-01 00:00:00

abstract：:Ewing-like sarcomas (ELS) are a heterogenous group of tumors that frequently affect pediatric and young adult patients. Accurate classification and distinction from the Ewing sarcoma family of tumor (ESFT) is decisive in patient management. ELS share a significant morphologic, immunohistochemical and clinical overlap ...

journal_title：Histology and histopathology

authors： Machado I,Navarro S,Llombart-Bosch A

更新日期：2016-11-01 00:00:00

abstract：:Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD), however, specific treatment for DN has not yet been elucidated. Therefore, it is critically important to understand the molecular mechanism underlying DN to develop cause-related therapeutic strategy. To date, various factors such as hemodyn...

journal_title：Histology and histopathology

authors： Kawanami D,Matoba K,Utsunomiya K

更新日期：2016-10-01 00:00:00

abstract：:Hereditary hemochromatosis (HH) is an inherited iron overload disorder characterized by normal iron-driven erythropoiesis and abnormal iron metabolism, leading to excess iron deposited in parenchymal cells of liver, heart, and endocrine glands. Iron hormone, hepcidin, plays a critical role in iron homeostasis through ...

journal_title：Histology and histopathology

authors： Liu J,Pu C,Lang L,Qiao L,Abdullahi MA,Jiang C

更新日期：2016-08-01 00:00:00

abstract：:The low density lipoprotein receptor-related protein (LRP) 1 is a ubiquitously expressed, versatile cell surface transmembrane receptor involved in embryonic development and adult tissue homeostasis. LRP1 binds and endocytoses a broad spectrum of over 40 ligands identified thus far, including lipoproteins, extracellul...

journal_title：Histology and histopathology

authors： Wujak L,Markart P,Wygrecka M

更新日期：2016-07-01 00:00:00

abstract：:Much effort has been made by researchers to elucidate the complex biology of breast cancer stem cells (BCSCs), a small subset of breast tumor cells that display stem cell properties, drive tumor initiation, and growth. In recent years, it has been suggested that BCSCs could be responsible for the process of metastasis...

journal_title：Histology and histopathology

authors： Schwarz-Cruz Y Celis A,Espinosa M,Maldonado V,Melendez-Zajgla J

更新日期：2016-06-01 00:00:00

abstract：:Autophagy and apoptosis are two important molecular mechanisms that maintain cellular homeostasis under stress conditions. Autophagy represents an intracellular mechanism responsible for turnover of organelles and long-lived proteins through a lysosome-dependent degradation pathway. Cell death signals or sustained str...

journal_title：Histology and histopathology

authors： Oral O,Akkoc Y,Bayraktar O,Gozuacik D

更新日期：2016-05-01 00:00:00

abstract：:The International Prognostic Index (IPI) has been the basis for determining prognosis in patients with diffuse large B-cell lymphoma (DLBCL) for the past 20 years. The utility of the IPI must be reassessed in the era of immunochemotherapy. Seven risk factors at diagnosis were identified, and a maximum of 7 points were...

journal_title：Histology and histopathology

authors： Wang J,Zhou M,Xu JY,Yang YG,Zhang QG,Zhou RF,Chen B,Ouyang J,Li C

更新日期：2016-03-01 00:00:00

abstract：:Despite years of research into its pathobiology and continuing clinical trials for novel therapies, the prognosis for patients with glioblastoma (GBM) remains dismal. An important obstacle against treatment efficacy may be a high degree of intra- and inter-tumoral heterogeneity within GBMs, which may be caused by the ...

journal_title：Histology and histopathology

authors： Lee HW,Lee K,Kim DG,Yang H,Nam DH

更新日期：2016-03-01 00:00:00

abstract：:Oligodendrocytes are the myelinating cells of the central nervous system. Since many studies of demyelinating diseases focus their research on this cell type, there is growing interest for obtaining reliable markers that can specifically recognize oligodendroglia. Established markers are the myelin-associated neurite ...

journal_title：Histology and histopathology

authors： Salinas Tejedor L,Gudi V,Kucman V,Pul R,Gingele S,Sühs KW,Stangel M,Skripuletz T

更新日期：2015-12-01 00:00:00

abstract：:Our study aimed to investigate the association of Pyruvate Kinase isozyme type M2 (PKM2) with radiation resistance in locally advanced cervical squamous cell carcinoma (LACSCC). We retrospectively reviewed 132 female patients who received primary radiation therapy to treat LACSCC at Federation Internationale of Gyneco...

journal_title：Histology and histopathology

authors： Zhao Y,Shen L,Chen X,Qian Y,Zhou Q,Wang Y,Li K,Liu M,Zhang S,Huang X

更新日期：2015-11-01 00:00:00

abstract：:Peritumoral brain edema (PTBE) is considered to be one of the main biological behaviors of brain glioma. However, the histopathological features of PTBE remain imprecisely defined. We analyzed the histopathological characteristics in the PTBE area of 22 cases of glioma. Microscopically, the pre-existing basic structur...

journal_title：Histology and histopathology

authors： Wang X,Liu X,Chen Y,Lin G,Mei W,Chen J,Liu Y,Lin Z,Zhang S

更新日期：2015-09-01 00:00:00

abstract：:The repair of articular cartilage defects is increasingly moving into the focus of experimental and clinical investigations. Histological analysis is the gold standard for a valid and objective evaluation of cartilaginous repair tissue and predominantly relies on the use of established scoring systems. In the past thr...

journal_title：Histology and histopathology

authors： Orth P,Madry H

更新日期：2015-08-01 00:00:00

abstract：:Strain injuries of tendons are the most common orthopedic injuries in athletic subjects, be they equine or human. When the tendon is suddenly damaged, an acute inflammatory phase occurs whereas its repetitive overloading may cause chronic injuries. Currently the criteria used for grading injuries are general and subje...

journal_title：Histology and histopathology

authors： Martinello T,Pascoli F,Caporale G,Perazzi A,Iacopetti I,Patruno M

更新日期：2015-08-01 00:00:00

abstract：:HPV infection has been identified recently as the causative agent of a subset of squamous cell carcinomas arising in oropharyngeal tonsils. Factors influencing the susceptibility of tonsillar epithelium to HPV-induced oncogenesis are far from being elucidated. A 5-protein signature including cytokeratin (CK)7, anterio...

journal_title：Histology and histopathology

authors： Morbini P,Capello GL,Alberizzi P,Benazzo M,Paglino C,Comoli P,Pedrazzoli P

更新日期：2015-07-01 00:00:00

abstract：:Mitochondrial transcription factor A (mtTFA) plays a crucial role in both the transcription and maintenance of mitochondrial DNA. A high expression of mtTFA has been demonstrated in several solid tumors, and is closely associated with cancer cell survival/apoptosis and growth. However, its expression pattern in pancre...

journal_title：Histology and histopathology

authors： Kimura T,Kitada S,Uramoto H,Zhi L,Kawatsu Y,Takeda T,Horie S,Nabeshima A,Noguchi H,Sasaguri Y,Izumi H,Kohno K,Yamada S

更新日期：2015-02-01 00:00:00

abstract：:Most patients with ovarian cancers relapse, and treatment failure has often been attributed to chemoresistance in tumor cells. Emerging evidence indicates that tumor heterogeneity may play an equally important role. Although the idea of tumor heterogeneity is not new, little attention has been focused on applying it t...

journal_title：Histology and histopathology

authors： Gui T,Cao D,Yang J,Shen K

更新日期：2015-02-01 00:00:00

abstract：:Heterotopic ossification (HO) is a debilitating condition in which cartilage and bone forms in soft tissues such as muscle, tendon, and ligament causing immobility. This process is induced by inflammation associated with traumatic injury. In an extremely rare genetic disorder called fibrodysplasia ossificans progessiv...

journal_title：Histology and histopathology

authors： Ramirez DM,Ramirez MR,Reginato AM,Medici D

更新日期：2014-10-01 00:00:00

abstract：:The population of the world grows every year, and life expectancy tends to increase. Thus, long-term preservation of teeth in aged individuals is an urgent issue. The main causes of tooth loss are well known to be periodontitis, caries, fractures, and orthodontic conditions. Although implant placement is a widely acce...

journal_title：Histology and histopathology

authors： Maeda H,Tomokiyo A,Wada N,Koori K,Kawachi G,Akamine A

更新日期：2014-10-01 00:00:00

abstract：:Since endometriosis is a proliferative disease we evaluated the presence of anti-apoptotic factor (Bcl-2) and pro-apoptotic factor (Bax) in deep pelvic endometriosis. A Cross-sectional observational study was performed at Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil. Forty women aged 26 to 46 years with ...

journal_title：Histology and histopathology

authors： Abdalla Ribeiro HS,Galvāo MA,Aoki T,Aldrighi JM,Ribeiro PA

更新日期：2014-09-01 00:00:00

abstract：:Tumorigenesis correlates with hypermethylation of tumor suppressors and hypomethylation of oncogenes. DNA methyltransferases (DNMTs) catalyze DNA methylation, and mutations and aberrant expression in DNMT genes are found in multiple human tumors. The discovery of the DNA demethylation function of TET proteins has open...

journal_title：Histology and histopathology

authors： Wu YC,Ling ZQ

更新日期：2014-08-01 00:00:00

abstract：:Introduction. Lichen planus (LP) is a chronic cytokine-mediated disease of possible auto-immune etiology. 25% of men have anogenital manifestations. Erosive penile LP causes a scarring phimosis of the foreskin in uncircumcised men. Mast cells as potent immune modulators have been implicated in a number of autoimmune a...

journal_title：Histology and histopathology

authors： Regauer S,Beham-Schmid C

更新日期：2014-08-01 00:00:00

abstract：:Cerebral cavernous malformations (CCMs) are described as vascular lesions consisting of endothelial-lined dilated vessels embedded in a connective tissue sheath without intervening parenchyma between them. Their anatomical connections with the normal blood vessels are still enigmatic and the fine three-dimensional (3-...

journal_title：Histology and histopathology

authors： Toralba S,Landemore G,Coquemont M,Plancoulaine B,Chapon F

更新日期：2014-08-01 00:00:00

abstract：:Although testicular germ cell tumors (TGCTs) are relatively uncommon, they are particularly important, as they tend to affect children and young men, the most common tumor being in males aged from 20 to 40 years, and the incidence has been increasing in the last years. TGCTs comprise two major histologic groups: semin...

journal_title：Histology and histopathology

authors： Chieffi P,Chieffi S

更新日期：2014-08-01 00:00:00

abstract：:We review the morphofunctional characteristics of CD34+ stromal fibroblastic/fibrocytic cells (CD34+ SFCs) and report our observations. We consider the following aspects of CD34+ SFCs: A) The confusing terms applied to this cell type, often combining the prefix CD34 with numerous names, including fibroblasts, fibrocyt...

journal_title：Histology and histopathology

authors： Díaz-Flores L,Gutiérrez R,García MP,Sáez FJ,Díaz-Flores L Jr,Valladares F,Madrid JF

更新日期：2014-07-01 00:00:00

abstract：:Immunohistochemistry of the terminal complement complex (C5b-9) and fibronectin (FN) is useful to detect myocardial ischemia preceding necrosis in the postmortem diagnosis of sudden cardiac death. The present immunohistochemical study examined connexin43 (Cx43) and zonula occludens-1 (ZO-1) as markers of early myocard...

journal_title：Histology and histopathology

authors： Kawamoto O,Michiue T,Ishikawa T,Maeda H

更新日期：2014-06-01 00:00:00

abstract：:Soft dental tissues have been identified as easily accessible sources of multipotent postnatal stem cells. Dental stem cells are mesenchymal stem cells (MSC) capable of differentiating into at least three distinct cell lineages: osteo/odontogenic, adipogenic and neurogenic. They express various markers including those...

journal_title：Histology and histopathology

authors： Bojic S,Volarevic V,Ljujic B,Stojkovic M

更新日期：2014-06-01 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase II (CaMKII) is considered one of the key intracellular signaling proteins for development of neuropathy. We analyzed the expression of total CaMKII (tCaMKII) and its alpha, beta, gamma and delta isoforms in dorsal root ganglia (DRG) in a rat model of Diabetes mellitus type I...

journal_title：Histology and histopathology

authors： Ferhatovic L,Jelicic Kadic A,Boric M,Puljak L

更新日期：2014-05-01 00:00:00

abstract：:"Classically activated macrophages (M1)" and "alternatively activated macrophages (M2)", which appear in injured tissues, control either inflammation or remodeling. The mechanism remains unclear. To clarify the M1-/M2-macrophage polarization in acute liver injury, M1- and M2-related factors were analysed in F344 rats ...

journal_title：Histology and histopathology

authors： Wijesundera KK,Izawa T,Murakami H,Tennakoon AH,Golbar HM,Kato-Ichikawa C,Tanaka M,Kuwamura M,Yamate J

更新日期：2014-04-01 00:00:00

abstract：AIMS:Gastric hyperplastic polyps (GHPs) are the most common polypoid lesion of the stomach, and their malignant potential has been demonstrated. In the present study, we evaluated the mucin phenotypes of GHPs and investigated the relationships among mucin phenotypes and clinical-pathological factors, proliferative acti...

journal_title：Histology and histopathology

authors： Li J,Wu LH,Shi Y,Li HM,Song MY,Jiao YF

更新日期：2014-03-01 00:00:00

abstract：:Differentiating nonspecific interstitial pneumonia (NSIP) from usual interstitial pneumonia (UIP) is important for the determination of both treatment and prognosis. Using two-dimensional fluorescence difference gel electrophoresis (2D-DIGE), we examined 8 UIPs, 8 NSIPs, and 30 normal lung tissues. Comparisons with co...

journal_title：Histology and histopathology

authors： Ohara I,Aida S,Shimazaki H,Kobayashi H,Tsuda H,Toda T,Nakanishi K,Tamai S

更新日期：2014-03-01 00:00:00

abstract：:High mobility group box 1 protein (HMGB1) is a non-histone chromosomal protein which is highly conserved, ubiquitous, and widely distributed. HMGB1 has multiple functions in the nucleus, including the maintenance of nucleosome structure, the regulation of gene transcription, and involvement in DNA recombination. HMBG1...

journal_title：Histology and histopathology

authors： Umahara T,Uchihara T,Koyama S,Hashimoto T,Akimoto J,Haraoka J,Iwamoto T

更新日期：2014-02-01 00:00:00

abstract：:Processing adult human trabecular bone to obtain tissue sections suitable for research or diagnostic purposes has always been challenging, particularly in the preparation of adult bone specimens for advanced immunohistochemistry applications. In contrast to the majority of soft tissues, decalcified bone samples perfor...

journal_title：Histology and histopathology

authors： Maly IP,Rahner C,Nowakowski AM,Müller-Gerbl M

更新日期：2013-12-01 00:00:00

abstract：:Bacillus subtilis has been used as a classic model to study biofilm formation and sporulation process. Colonies of wild-type strains usually have a complex external morphology, but the details of their internal architecture are still undisclosed. Since bacterial biofilms fulfill the criteria to be considered tissues, ...

journal_title：Histology and histopathology

authors： Gómez-Aguado F,Corcuera MT,Gómez-Lus ML,de la Parte MA,Ramos C,García-Rey C,Alonso MJ,Prieto J

更新日期：2013-10-01 00:00:00

abstract：:Early observations that cultured mesenchymal stem cells (MSCs) could be induced to exhibit certain characteristics of osteocytes and chondrocytes led to the proposal that they could be transplanted for tissue repair through cellular differentiation. Therefore, many subsequent preclinical studies with transplanted MSCs...

journal_title：Histology and histopathology

authors： Lin CS,Xin ZC,Dai J,Lue TF

更新日期：2013-09-01 00:00:00

abstract：:Cocaine- and amphetamine-regulated transcript peptide (CART) is a neuromediator and/or neuromodulator in nerve structures within the gastrointestinal tract, but knowledge about its distribution, functions and co-localisation with other neuronal factors, especially in humans, is very scarce. During the present investig...

journal_title：Histology and histopathology

authors： Gonkowski S,Kamińska B,Landowski P,Całka J

更新日期：2013-07-01 00:00:00

abstract：:Besides microfilaments and microtubules, intermediate filaments are major components of the cytoskeleton. In epithelial cells intermediate filaments are formed by heterodimers of specific keratins, whose expression pattern highly depends on the type of epithelium and differentiation degree of the cell. During the proc...

journal_title：Histology and histopathology

authors： Gauster M,Blaschitz A,Siwetz M,Huppertz B

更新日期：2013-07-01 00:00:00

abstract：:Versican, a large extracellular matrix proteoglycan accumulates in tumor stroma and plays a key role in both malignant transformation and tumor progression. Increased versican expression has been observed in a wide range of malignant tumors, and has been associated with both cancer relapse and poor patient outcomes in...

journal_title：Histology and histopathology

authors： Du WW,Yang W,Yee AJ

更新日期：2013-06-01 00:00:00

abstract：:Chronic liver diseases are commonly associated with tissue hypoxia that may cause inflammation, oxidative stress, liver cell injury and increased nuclear transcriptional regulation. The hepatic response to chronic hypoxia at the molecular level has not yet been clearly understood until now. The aim of this study is to...

journal_title：Histology and histopathology

authors： Lau TY,Xiao J,Liong EC,Liao L,Leung TM,Nanji AA,Fung ML,Tipoe GL

更新日期：2013-04-01 00:00:00